MTHFR Gene

Possibly the reason for your Depression, Chronic fatigue, Fibromyalgia or Irritable Bowel Syndrome

 MTHFR is shorthand for Methyl Tetra Hydra Folate Reductase, an enzyme that is primarily responsible for the process of methylation within the body.  It is most notable for changing homocysteine into methionine.  This enzyme is also involved in the production of many neurotransmitters, such as dopamine, serotonin & norepinephrine, as well as SAMe and glutathione, which is a pivotal anti-oxidant molecule involved in the body’s natural detoxification process.

There are many variations of this gene, but the two most common are known as 677 and 1298, the numbers make reference to the specific location on the gene where the abnormality is located.  These variants produce a MTHFR enzyme that is 30-60% less active than normal.

Having one or two of the lower functioning variants can contribute to symptoms of:

  • Cardiovascular risk associated with elevated Homocysteine, including atherosclerosis, heart attack, stroke, and deep vein thromboses.
  • Folate deficiency related pregnancy & development problems, including still-births/miscarriages, pre-eclampsia, and neural defects (cleft lip, cleft palate, etc.)
  • Brain Neurotransmitter issues, like depression, anxiety, insomnia, dementia, schizophrenia, Parkinson’s, and addiction.
  • Significantly diminished ability for detoxification, especially heavy metals, high oxidative stress in all body systems; which can contributes to immune disorders, allergies, autoimmune issues, fatigue, headaches, insomnia, mood issues, thyroid and menstrual disorders, kidney damage, neurological symptoms, cancer risk.
  • Complex disorders that usually cascade from a combination of issues above, include fibromyalgia, chronic fatigue, irritable bowel syndrome, autism spectrum disorders, and peripheral neuropathy.
  • Other associates diseases, not caused by MTHFR, but significantly complicated by it, such as diabetes, lymphoma and Leiden factor V, a blood clotting disorder.

How do I know if I have a mutation within my MTHFR gene?  A simple blood test, which is covered by most insurance companies can deliver results within a couple of weeks.  How is MTHFR gene mutations treated?  Enzyme deficiency is correctable by supplementing a special form of folate in very high doses, which is available by prescription.  Many patients that have these less-than-optimal gene experiences experience significant and sometimes dramatic improvement once beginning MTHF Repletion protocol.  The protocol is simple and affordable. 

Our practitioners are capable to test individuals for this genetic mutation.  Please contact our office for more information or to consult with our Naturopaths.